Paradigm BioCapital Advisors LP (“PBCA”, the “Firm” or the “Investment Manager”) is a Delaware limited partnership that was formed in July 2020. The general partner of PBCA is Paradigm BioCapital Advisors GP LLC (“PBCAGP”). Dr. Senai Asefaw (the “Principal”) is the managing member and principal owner of PBCAGP. PBCA provides investment advisory services to private funds via a master-feeder structure, whereby Paradigm BioCapital Partners Fund, LP (the “Domestic Fund”), a Delaware limited partnership, and Paradigm BioCapital Partners Fund, Ltd. (the “Offshore Fund”) a Cayman Islands exempted company together with the Onshore Fund, the “Feeder Funds”, invest substantially all of their assets in Paradigm BioCapital International Fund Ltd. (the “Master Fund”), a Cayman Islands exempted company. Unless otherwise specified, the Domestic Fund, the Offshore Fund and the Master Fund are each referred to as a “Fund” and collectively, as the “Funds”. Additionally, PBCA manages one separately managed account on a discretionary basis pursuant to an Investment Management Agreement with the underlying investor (the “SMA”). Hereinafter, where applicable, the Funds and the SMA are collectively referred to as the “Clients”. PBCA manages the Funds pursuant to investment guidelines set forth in the relevant governing and offering documents of the Funds, including any limited partnership agreement, investment management agreement, private placement memorandum and/or subscription agreement (each an “Offering Document”, and collectively, the “Offering Documents”). The Offering Documents contain more detailed information about the Funds, including a description of the investment objective and strategy or strategies employed by the Funds and related restrictions that serve as a limitation on PBCA’s advice or management. PBCA will not tailor its advisory services to the individual investors in the Funds (each an “Investor” and

collectively the “Investors”), or provide Investors with the right to specify, or restrict the Funds’ investment objectives or any investment or trading decisions. Accordingly, an investment in a Fund does not create a client-adviser relationship between such Investors and PBCA. Each of the Funds are expected to rely on the exception from the definition of an “investment company” provided by Section 3(c)(7) of the U.S. Investment Company Act of 1940, as amended (the “1940 Act”). Each Investor is strongly encouraged to undertake appropriate due diligence, including but not limited to a review of relevant Offering Documents and the additional details about PBCA’s investment strategies, methods of analysis and related risks (as discussed in Item 8 of this Brochure and each Fund’s Offering Documents) in considering whether PBCA’s advisory services, or an investment in a Fund are appropriate to its own circumstances, based on all relevant factors including, but not limited to, the Investor’s own investment objectives, liquidity requirements, tax situation and risk tolerance before making an investment decision. The general partner of the Onshore Fund and Master Fund is Paradigm BioCapital GP LLC (the “General Partner”), a Delaware limited liability company. The General Partner has ultimate responsibility for decisions relating to management and operations made on behalf of the Domestic Fund and the Master Fund and has ultimate responsibility for the investment decisions made on behalf of the Master Fund but has delegated certain responsibilities to PBCA. Additional detailed information about PBCA is provided below, including information about PBCA’s advisory services, investment approach, personnel and affiliations. PBCA does not participate in wrap fee programs. PBCA currently provides discretionary investment advisory services to the Clients with a total of $2,358,206,292 in regulatory assets under management.